The A605 at Ralph Butcher Causeway is currently closed because of a crane fire.
Police and fire crews are currently at the scene.
A post on the Policing Fenland page on Facebook has warned drivers the road will be closed for the "foreseeable future".
Motorists are being advised to use an alternative route.
It said: "A605 closed at the Ralph Butchers causeway towards Whittlesey, for the foreseeable future.
"Please find an alternative route."
An East of England Ambulance spokesman said no medics were needed at the scene.
A Cambridgeshire Constabulary spokesperson said: "We were called by the fire service advising us that there was a crane is on fire at Peterborough Road, Whittlesey at about 7.54am today (Monday April 24). There has also been an oil spillage.
"The A605 remains closed at the Ralph Butchers causeway towards Whittlesey while recovery takes place."
A Cambridgeshire Fire & Rescue Service spokesperson said: "On Monday (April 24) at 7.46am, a crew from Dogsthorpe and a crew form Stanground were called to a lorry fire on Peterborough Road, Whittlesey.
"Crews arrived to find a mobile crane on fire in close proximity to houses.
"Wearing breathing apparatus, firefighters used hose reels to extinguish the fire.
"There were no casualties.
The road is likely to be closed for some time due to a fuel spillage.
"The cause of the fire was accidental.
"One crew remains in attendance."
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