Fly-tippers dumped enough waste to fill two bin lorries in a single layby.
Fenland council says the site at Friday Bridge, near Wisbech, was targeted almost 40 times last year.
It said it cleared 22 tonnes of commercial and household waste - enough to fill two refuse vehicles - from it.
It comes amid grim warnings about the extent of fly-ripping across the region as councils increase penalty charges for any culprits they track down.
The Friday Bridge operation was funded by a £2,400 grant from the Cambridgeshire police and crime commissioner.
A soil and concrete bank has been built to make it harder to unload items at the site, while warning signs have also been put up.
Peter Murphy, Fenland's portfolio holder for the environment, said: "Now the site has been cleared, should anyone choose to fly-tip there again our enforcement officers will have much more opportunity to find the evidence they need to trace it back and prosecute.
"We hope it doesn't come to that and that now this site is clear there'll be a new respect for the area and residents and wildlife can be free of this nuisance and pollution."
Cambridgeshire's police and crime commissioner Darryl Preston said: "Fly-tipping is a crime and completely unacceptable in our communities. It can have a significant environmental and health impact, as well as a financial burden on law-abiding citizens and our public services."
As yet, the Friday Bridge fly-tippers have not been caught.
There are fears plans to close council recycling centres one day a week in neighbouring Norfolk will lead to yet more illegal dumping, along with plans to make householders make appointments to bring in their rubbish, will make the problem worse.
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